Structure of PDB 8tc5 Chain C Binding Site BS01

Receptor Information
>8tc5 Chain C (length=1087) Species: 231513 (Civet SARS CoV SZ3/2003) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSN
VTGFHTINHTFDNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVI
IINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYIS
DAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNT
LKPIFKLPLGIKITNFRAILTAFLPAQDTWGTSAAAYFVGYLKPTKFMLK
YDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVR
FPNITNLCPFGEVFNATKFPSVYAWERKRISNCVADYSVLYNSTSFSTFK
CYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDD
FMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGK
PCTPPALNCYWPLKDYGFYTTSGIGYQPYRVVVLSFELLNAPATVCGPKL
STDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDP
KTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDAWRIYSTGNN
VFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVQKSIVAYTMSLGAD
SSIAYSNNTIAIPTNFLISITTEVMPVSMAKTSVDCNMYICGDSTECANL
LLQYGSFCAQLNRALSGIAVEQDRNTREVFAQVKQMYKTPTLKDFGGFNF
SQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICA
QKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQM
AYRFNGIGVAQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVV
NQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQ
SLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSF
PQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSW
FITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYD
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain8tc5 Chain m Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tc5 Cryo-EM reveals variation in structural motifs within animal SARS-related coronavirus spike proteins
Resolution2.11 Å
Binding residue
(original residue number in PDB)		Q773 S901
Binding residue
(residue number reindexed from 1)		Q752 S880
Annotation score4
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tc5, PDBe:8tc5, PDBj:8tc5
PDBsum8tc5
PubMed38805567
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

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