Structure of PDB 8t10 Chain C Binding Site BS01
Receptor Information
>8t10 Chain C (length=301) Species:
10116
(Rattus norvegicus) [
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IDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYF
NFFVYCLYMIIFTAAAYYRPVLPPYKLKNTVGDYFRVTGEILSVSGGVYF
FFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYV
ASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFL
FGFSTAVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFII
LLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKS
F
Ligand information
Ligand ID
NKN
InChI
InChI=1S/C17H35O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(19)23-14-16(18)15-24-25(20,21)22/h16,18H,2-15H2,1H3,(H2,20,21,22)/t16-/m1/s1
InChIKey
FAZBDRGXCKPVJU-MRXNPFEDSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.7.0
CCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O
CACTVS 3.370
CCCCCCCCCCCCCC(=O)OC[CH](O)CO[P](O)(O)=O
ACDLabs 12.01
O=P(OCC(O)COC(=O)CCCCCCCCCCCCC)(O)O
OpenEye OEToolkits 1.7.0
CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)O
CACTVS 3.370
CCCCCCCCCCCCCC(=O)OC[C@@H](O)CO[P](O)(O)=O
Formula
C17 H35 O7 P
Name
(2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate;
14:0 LPA;
myristoyl lysophosphatidic acid
ChEMBL
CHEMBL1615121
DrugBank
ZINC
PDB chain
8t10 Chain C Residue 901 [
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Receptor-Ligand Complex Structure
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PDB
8t10
Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Resolution
3.7 Å
Binding residue
(original residue number in PDB)
Y511 F543 A546 M547 T550 L553 Y554
Binding residue
(residue number reindexed from 1)
Y123 F155 A158 M159 T162 L165 Y166
Annotation score
1
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0004888
transmembrane signaling receptor activity
GO:0005216
monoatomic ion channel activity
GO:0005230
extracellular ligand-gated monoatomic ion channel activity
GO:0005231
excitatory extracellular ligand-gated monoatomic ion channel activity
GO:0005261
monoatomic cation channel activity
GO:0005262
calcium channel activity
GO:0005515
protein binding
GO:0005516
calmodulin binding
GO:0005524
ATP binding
GO:0008289
lipid binding
GO:0008324
monoatomic cation transmembrane transporter activity
GO:0015276
ligand-gated monoatomic ion channel activity
GO:0015278
intracellularly gated calcium channel activity
GO:0017081
chloride channel regulator activity
GO:0035091
phosphatidylinositol binding
GO:0042802
identical protein binding
GO:0046872
metal ion binding
GO:0051219
phosphoprotein binding
GO:0097603
temperature-gated ion channel activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001659
temperature homeostasis
GO:0001660
fever generation
GO:0001774
microglial cell activation
GO:0002024
diet induced thermogenesis
GO:0002790
peptide secretion
GO:0003085
negative regulation of systemic arterial blood pressure
GO:0006629
lipid metabolic process
GO:0006811
monoatomic ion transport
GO:0006816
calcium ion transport
GO:0007204
positive regulation of cytosolic calcium ion concentration
GO:0009268
response to pH
GO:0009408
response to heat
GO:0010459
negative regulation of heart rate
GO:0010917
negative regulation of mitochondrial membrane potential
GO:0014047
glutamate secretion
GO:0014832
urinary bladder smooth muscle contraction
GO:0019233
sensory perception of pain
GO:0019722
calcium-mediated signaling
GO:0034220
monoatomic ion transmembrane transport
GO:0034605
cellular response to heat
GO:0043065
positive regulation of apoptotic process
GO:0043434
response to peptide hormone
GO:0045429
positive regulation of nitric oxide biosynthetic process
GO:0048265
response to pain
GO:0048266
behavioral response to pain
GO:0050909
sensory perception of taste
GO:0050954
sensory perception of mechanical stimulus
GO:0050955
thermoception
GO:0050960
detection of temperature stimulus involved in thermoception
GO:0050965
detection of temperature stimulus involved in sensory perception of pain
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
GO:0051289
protein homotetramerization
GO:0055085
transmembrane transport
GO:0060079
excitatory postsynaptic potential
GO:0060083
smooth muscle contraction involved in micturition
GO:0070588
calcium ion transmembrane transport
GO:0071312
cellular response to alkaloid
GO:0071318
cellular response to ATP
GO:0071345
cellular response to cytokine stimulus
GO:0071356
cellular response to tumor necrosis factor
GO:0071363
cellular response to growth factor stimulus
GO:0071468
cellular response to acidic pH
GO:0071502
cellular response to temperature stimulus
GO:0090212
negative regulation of establishment of blood-brain barrier
GO:0098703
calcium ion import across plasma membrane
GO:1901594
response to capsazepine
GO:1990090
cellular response to nerve growth factor stimulus
Cellular Component
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0016020
membrane
GO:0030425
dendrite
GO:0032591
dendritic spine membrane
GO:0042995
cell projection
GO:0043005
neuron projection
GO:0043025
neuronal cell body
GO:0045202
synapse
GO:0045211
postsynaptic membrane
GO:0098982
GABA-ergic synapse
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8t10
,
PDBe:8t10
,
PDBj:8t10
PDBsum
8t10
PubMed
38698206
UniProt
O35433
|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)
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