Structure of PDB 8spu Chain C Binding Site BS01

Receptor Information
>8spu Chain C (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNI
QAVLLPK
Ligand information
>8spu Chain J (length=149) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgctgattccctccattcgctctgcataactatcactttctggaactcca
tggtctcctaggtcgccaggcctttgctttgcagcttagaacagactctc
tatgctccctccaccctctgtttctccaggtcccacatggggaggcgct
Receptor-Ligand Complex Structure
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PDB8spu Structural mechanism of LIN28B nucleosome targeting by OCT4.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 G44 R77
Binding residue
(residue number reindexed from 1)		R18 R31 V32 G33 R66
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008150 biological_process
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8spu, PDBe:8spu, PDBj:8spu
PDBsum8spu
PubMed37327775
UniProtQ16777|H2A2C_HUMAN Histone H2A type 2-C (Gene Name=H2AC20)

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