Structure of PDB 8rgh Chain C Binding Site BS01

Receptor Information
>8rgh Chain C (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSDAVVMPKIDTPRLCSFLRAACQVMAVLLEEDRLAAEPSWNLRAQDRAL
YFSDSSSQLNTSLPFLQNRKVSSLHTSRVQRQMVVSVHDLPEKSFVPLLD
SKYVLCVWDIWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGSVVV
WDLREDSRLHYSVTLSDGFWTFRTATFSTDGILTSVNHRSPLQAVEPIST
SMSGLSFHIASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVH
SALIQLGDSLSHKGNEFWGTTQTLNVKFLPSDPNHFIIGTDMGLISHGTR
QDLRVAPKLFKPQQHGIRPVKVNVIDFSPFGEPIFLAGCSDGSIRLHQLS
SAFPLLQWDSSTDSHAVTGLQWSPTRPAVFLVQDDTSNIYIWDLLQSDLG
PVAKQQVSPNRLVAMAAVGEPEKAGGSFLALVLARASGSIDIQHLKRRWA
APEVDECNRLRLLLQEA
Ligand information
>8rgh Chain E (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RDPQYAENEVDEMRIQKDLELEQYKRS
Receptor-Ligand Complex Structure
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PDB8rgh Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S575 I583 D584 P586 R593
Binding residue
(residue number reindexed from 1)		S2 I10 D11 P13 R20
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0045503 dynein light chain binding
GO:0045504 dynein heavy chain binding
Biological Process
GO:0030030 cell projection organization
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0048704 embryonic skeletal system morphogenesis
GO:0060271 cilium assembly
Cellular Component
GO:0000242 pericentriolar material
GO:0000922 spindle pole
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005929 cilium
GO:0031021 interphase microtubule organizing center
GO:0097542 ciliary tip
GO:0097546 ciliary base

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rgh, PDBe:8rgh, PDBj:8rgh
PDBsum8rgh
PubMed38454149
UniProtQ8WVS4|DC2I1_HUMAN Cytoplasmic dynein 2 intermediate chain 1 (Gene Name=DYNC2I1)

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