Structure of PDB 8r23 Chain C Binding Site BS01

Receptor Information
>8r23 Chain C (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYI
TQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICP
ILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIK
AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLI
TESTYATTIRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETF
WERMNLKVPIYFSTGLTEKANHYYKLFIPWTEFKHIKAFDRAFADNPGPM
VVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRK
LEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKK
MEFLKQKIEQELRVNCYMPANGETVTLPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8r23 Chain C Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8r23 Assembly mechanism of Integrator's RNA cleavage module.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H68 H70 H157 D178
Binding residue
(residue number reindexed from 1)		H67 H69 H156 D177
Annotation score4
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8r23, PDBe:8r23, PDBj:8r23
PDBsum8r23
PubMed39032489
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

[Back to BioLiP]