Structure of PDB 8qdx Chain C Binding Site BS01

Receptor Information
>8qdx Chain C (length=837) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNV
LGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVD
GQGNFGSIDGDSAAAMRFTEIRLAKIAHELMADLEKETVDFVDNYDGTEK
IPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDIS
IEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKT
GRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIV
IEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAF
VRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPA
EAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQ
AQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIRE
ELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPL
SEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKV
YQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGT
VKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVV
RFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGK
RTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTL
VRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAE
Ligand information
>8qdx Chain E (length=118) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8qdx Structural basis of DNA crossover capture by E. coli DNA gyrase
Resolution3.0 Å
Binding residue
(original residue number in PDB)		V44 H45 H78 H80 T88 R91 S172 R272 R561 R562 K565 K567 T611 R612 R615 R617 R705 C716 T719 G720 R722 R766 K769 G770 N818 Q820 G821
Binding residue
(residue number reindexed from 1)		V40 H41 H74 H76 T84 R87 S168 R268 R557 R558 K561 K563 T607 R608 R611 R613 R701 C712 T715 G716 R718 R762 K765 G766 N814 Q816 G817
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0042802 identical protein binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
GO:2000104 negative regulation of DNA-templated DNA replication
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qdx, PDBe:8qdx, PDBj:8qdx
PDBsum8qdx
PubMed38603484
UniProtP0AES4|GYRA_ECOLI DNA gyrase subunit A (Gene Name=gyrA)

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