Structure of PDB 8qbd Chain C Binding Site BS01

Receptor Information
>8qbd Chain C (length=271) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHRTYSLRNSRAPTASQLQNPPPPPSTTKGRFFGKGGLAYSFRRSAAGAF
GPELSRKLSQLVKIEKNVLRSMELTANERRDAAKQLSIWGLENDDDVSDI
TDKLGVLIYEVSELDDQFIDRYDQYRLTLKSIRDIEGSVQPSRDRKDKIT
DKIAYLKYKDPQSPKIEVLEQELVRAEAESLVAEAQLSNITRSKLRAAFN
YQFDSIIEHSEKIALIAGYGKALLELLDDSPVTPGETRPAYDGYEASKQI
IIDAESALNEWTLDSAQVKPT
Ligand information
Ligand IDI3P
InChIInChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2+,3+,4-,5-,6-/m1/s1
InChIKeyMMWCIQZXVOZEGG-XJTPDSDZSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1OP(=O)(O)O)(O)O
OpenEye OEToolkits 1.5.0C1(C(C(C(C(C1OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O)[CH]1O[P](O)(O)=O
OpenEye OEToolkits 1.5.0[C@H]1([C@@H]([C@H]([C@@H]([C@H]([C@@H]1OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
CACTVS 3.341O[C@@H]1[C@H](O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@@H](O)[C@@H]1O[P](O)(O)=O
FormulaC6 H15 O15 P3
NameD-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
ChEMBLCHEMBL279107
DrugBankDB03401
ZINCZINC000004095598
PDB chain8qbd Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8qbd Real-space refinement in PHENIX for cryo-EM and crystallography.
Resolution3.61 Å
Binding residue
(original residue number in PDB)		K63 R126 K130
Binding residue
(residue number reindexed from 1)		K63 R126 K130
Annotation score4
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006897 endocytosis
GO:0008104 protein localization
GO:0070941 eisosome assembly
GO:0097446 protein localization to eisosome filament
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0032126 eisosome
GO:0036286 eisosome filament
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qbd, PDBe:8qbd, PDBj:8qbd
PDBsum8qbd
PubMed39048819
UniProtP53252|PIL1_YEAST Sphingolipid long chain base-responsive protein PIL1 (Gene Name=PIL1)

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