Structure of PDB 8ovj Chain C Binding Site BS01

Receptor Information
>8ovj Chain C (length=366) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPSVSVYSASSDSVVGTCPLPAVFTAPIRSDIVKFVHTNMAKNSRQAYAV
NRLSGMNHSAHSWGTGRAVARIPRISGGGTSTSGAGAFGNMCRGGRMFAP
TKIFRRWHRKINLHQKRFAVVSALAASSVPSLVMSRGHQIGNVPEVPLVV
EDSIQGYEKTKEAMAFLKAIAAIDDVNRVNDSREIRAGRGKMRNRRYVAR
RGPMLVMPNNKGTRAFRNIFGLDLANVSALNLLHLAPGGHVGRFVIWTQS
AFEQLDKIFGTFTEASAVKKGFTLPAPMLTNTDVTRIMQSEEVRRVLKPK
KLQAKKASRFQTPTNGMKNRRLRLRLNPYVKRETAAAKGMRNVANRDARR
KAKLARVTKAKKAATK
Ligand information
>8ovj Chain 1 (length=1611) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccgu
ugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcc
cauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuu
gggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagc
acuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaugg
aaguaccuccauuucaacggccagaaccagcccuacugcauuauccuguc
ggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaa
augagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuu
cuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucu
ugaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugcc
aguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugc
acacgucaaauccguuugauuugcccaacaccgaccggcccuccgugggu
ugcguuggagugugccuguuuggacccgaaagguggugaacuaugccuga
acaaggugaagcccggggaaacccagguggaggccuguagcgaugcugac
gugcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaac
caccuaguagcugguucacaucgaaguuucccucaggauagcuggugcua
guagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaa
acuuuaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaag
aaaagaauuagaggcaccaagugggccuucuucgguaagcggagcaggcg
augcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcuca
uucucgauacgugaaaaggguugguggauccaccggccccgaaaauggau
gacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgg
aaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguu
aggacgaagcuuauggcgugagccuaagauggaccggccucuagugcaga
ucuugguuggcguagcaaagaucuaacggagauauacucaacaugcaacg
uuggauacuggagcggggaaggauuucgugccaacggcacucguacacga
guuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaa
ggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaa
uugcauguggg
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......
>>>>.....<<........>>......>>>.<<.......((.....>>)
).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<..
......>>>>>>>.....<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<
<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>...
.....<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..
>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<..
......>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.....
...>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<..
.<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>
>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.
....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>.
.>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>....
.......>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
..<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<...
.....<...........<<<<<<<<<<..>>>>>>>>>>...........
))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...
.......>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<
........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>....
.>>>>>>..............<<<<<<<....................>>
>>>>>....................<<<<<....<<.....>>..>>>>>
....<<..........<<.<<<<<......>>>>...............<
<...>>......>.>>..........<<<<.........>>....>>.>>
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)
R32 K37 F38 N46 R48 Q49 Y51 R55 L56 S57 M59 H61 S62 V72 R74 P76 G81 G82 T83 A88 N93 M94 R96 G97 R99 M100 F101 K105 F107 R109 K113 N115 H117 Q118 R120 R139 K162 T163 R181 E187 R189 A190 G191 R192 M195 R196 R198 Y200 R203 R204 R217 N221 N234 G241 H243 K272 K273 R297 K304 L305 Q306 K308 K309 R312 F313 Q314 T317 N318 N322 R323 R324 R326 Y332 K334 R335 A339 K341 M343 R344 R349 R352 L357 R359 A363 A366
Binding residue
(residue number reindexed from 1)
R29 K34 F35 N43 R45 Q46 Y48 R52 L53 S54 M56 H58 S59 V69 R71 P73 G78 G79 T80 A85 N90 M91 R93 G94 R96 M97 F98 K102 F104 R106 K110 N112 H114 Q115 R117 R136 K159 T160 R178 E184 R186 A187 G188 R189 M192 R193 R195 Y197 R200 R201 R214 N218 N231 G238 H240 K269 K270 R294 K301 L302 Q303 K305 K306 R309 F310 Q311 T314 N315 N319 R320 R321 R323 Y329 K331 R332 A336 K338 M340 R341 R346 R349 L354 R356 A360 A363
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtE9ADW5

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