Structure of PDB 8oib Chain C Binding Site BS01

Receptor Information

>8oib Chain C (length=331) Species: 5722 (Trichomonas vaginalis)

MSIKCALDCDPGHDDLAMIMLAVYSPKLDVQYISTTHGNQTVNKTYQNAR
RTLNLIKRADKIPVYRGYSKPLTRESVACPEIHGESGLGGVDWSEIDRTM
PRNPALDILGYKDESELRPDDFFKHLHRLVSAAEDKFDIISTGSETNIAQ
YLLAYPEDAKKIRMTTMAGNFMIVGNIMPFAEFNVLIDPEAISNILQSGV
DYTFAAPLDITHTVLVTEKVINDIKAATEPYSPMIIKLLFFFKDTYRDVF
GFIDPPLHDPVAAFHLIAPEWFEHVRCHVDIETKGEYTYGCCCTNLIVKP
DNATVCLKLKEGGHDAFWNQMITVWGEIAKE

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8oib Chain C Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8oib A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis.
• Resolution: 2.44 Å
• Binding residue (original residue number in PDB): D10 D15 T142 D263
• Binding residue (residue number reindexed from 1): D10 D15 T142 D259
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0008477 purine nucleosidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006152 purine nucleoside catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8oib, PDBe:8oib, PDBj:8oib
• PDBsum: 8oib
• PubMed: 37482279
• UniProt: A2FTT0