Structure of PDB 8of0 Chain C Binding Site BS01

Receptor Information

>8of0 Chain C (length=258) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQ
IDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEF
TLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRQDDILIVKLRKGQELRLR
AYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELD
EDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQ
LSHEIQSD

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8of0 Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8of0 Structure of transcribing RNA polymerase II-Elongin complex
Resolution	3.05 Å
Binding residue (original residue number in PDB)	C88 C90 C94 C97
Binding residue (residue number reindexed from 1)	C87 C89 C93 C96
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003899	DNA-directed 5'-3' RNA polymerase activity
GO:0046983	protein dimerization activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006366	transcription by RNA polymerase II

	Cellular Component
GO:0000428	DNA-directed RNA polymerase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	RNA polymerase II, core complex
GO:0005829	cytosol

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8of0, PDBe:8of0, PDBj:8of0
PDBsum	8of0
PubMed	37932450
UniProt	I3LCH3

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