Structure of PDB 8kcw Chain C Binding Site BS01

Receptor Information

>8kcw Chain C (length=626) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPV
LVVVRQQKEVLSWQVPLLFQGLYQRSYNYQEVSRTLCPSEATNETGPLQQ
LIFVDVASMAPLGAQYKLLVTKLKHFQLRTNVAFHFTASPSQPQYFLYKF
PKDVDSVIIKVVSEMAYPCSVVSVQNIMCPVYDLDHNVEFNGVYQSMTKK
AAITLQKKDFPGEQFFVVFVIKPEDYACGGSFQTWNLQRKKNLEVTIVPS
IKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYYFWNIITIAVFYALPVIQ
LVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNLGHVLLGFLF
LLIVLRRDILHRRALEAEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPN
YSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVL
GVVFGKNDVWFWVIFSAIHVLASLALSTQIYMDRMVLLVVGNLVNWSFAL
FGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVLPVPLFCIVA
TAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSA
TALFFSFLVLLTLDDDLDVVRRDQIP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8kcw Chain C Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8kcw Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity.
Resolution	2.77 Å
Binding residue (original residue number in PDB)	H563 D574 H791 H795
Binding residue (residue number reindexed from 1)	H396 D407 H592 H596
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8kcw, PDBe:8kcw, PDBj:8kcw
PDBsum	8kcw
PubMed	38811802
UniProt	Q9NXL6\|SIDT1_HUMAN SID1 transmembrane family member 1 (Gene Name=SIDT1)

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