Structure of PDB 8k60 Chain C Binding Site BS01

Receptor Information
>8k60 Chain C (length=1116) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTAPLRISFAKIKEPLEVPNLLALQTESFDWLLGNDAWKARVESALESG
QDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPKNSIDECKDRDF
TYAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVVVS
QLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRID
RKRKQSVTVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDI
YRKLRPGEPPTREAAQTLLENLYFNPKRYDLAKVGRYKVNKKLGADEPLD
AGVLTTDDVIATIKYLVKLHAGETETVGESGREIVVETDDIDHFGNRRIR
NVGELIQNQVRTGLARMERVVRERMTTQDVEAITPQTLINIRPVVASIKE
FFGTSQLSQFMDQNNPLSGLTHKRRLNALGPGGLSRERAGFEVRDVHPSH
YGRMCPIETPEGPNIGLIGSLASYGRINPFGFIETPYRKVVEGQVTDDVD
YLTADEEDRFVIAQANAALGDDMRFAEARVLVRRRGGEVDYVPGDDVDYM
DVSPRQMVSVATAMIPFLEHDDANRALMGANMMRQAVPLIKSESPLVGTG
MEYRSAADAGDVVKAEKAGVVQEVSADYITTTNDDGTYITYRLAKFSRSN
QGTSVNQKVIVAEGDRIIEGQVLADGPATENGEMALGKNLLVAFMPWEGH
NYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVSEE
VLADLDERGIIRIGAEVVAGDILVGKVTPKGETELTPEERLLRAIFGEKA
REVRDTSLKVPHGEIGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKI
TDGDKLAGRHGNKGVISKINPIEDMPFLEDGTPVDIILNPLAVPSRMNPG
QVLEIHLGWLASRGWDVSGLAEEWAQRLQVIGADKVEPGTNVATPVFDGA
REDELAGLLQHTIPNRDGERMVLPSGKARLFDGRSGEPFPEPISVGYMYI
LKLHHLVDDKLHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYG
AAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQS
LCLNVEVLSSDGMSIE
Ligand information
>8k60 Chain G (length=56) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gagcgttcagcgttcgtttatctccccctggtataatgggagctgtcacg
gatgca
Receptor-Ligand Complex Structure
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PDB8k60 Structural insights into transcription activation of the Streptomyces antibiotic regulatory protein, AfsR
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R196 G197 W199 R216 R293 L449 E452 R453
Binding residue
(residue number reindexed from 1)		R181 G182 W184 R201 R278 L434 E437 R438
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k60, PDBe:8k60, PDBj:8k60
PDBsum8k60
PubMed39108719
UniProtQ9L0L0|RPOB_STRCO DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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