Structure of PDB 8jq3 Chain C Binding Site BS01

Receptor Information

>8jq3 Chain C (length=411) Species: 47715 (Lacticaseibacillus rhamnosus)

MVKPEEVDKAYEVAKQRYAEIGVDTDAAMKELEKVPLSVHCWQGDDIHGF
LFPNGNYPGIARTPDELAGDMHEALSLIPGKHRVQLHAIYAVTDKKRDLD
TLEPEDFDYWIDWAKQEGVGLDFNGTFFSHPMVKDNMTVSSPDPKVRDFW
IRHGKISREISNYIGEKLGSQVVNNFWLPDGFKDNPIDKKTPRLRLLKAL
DEIIKDPLPEKNTIESFEGKLFGTGIESYTTGSHEFYQNYAISRNKLWTI
DAGHFHPTEDVSDKFSAFFPFGKGLFMHVSRPVRWDSDHVVIMDDALIRI
TRSLVRDGYLDRTHIGLDFFDATINRVAAWVVGARATQKSLLQAMLAPID
QLKKDELNADFTTRLIETEELKSFPFGAVWDKFCQDHNTPVGFDWMNNIH
QYEKDVQFKRD

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8jq3 Chain C Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jq3 X-ray structure and characterization of a probiotic Lactobacillus rhamnosus Probio-M9 L-rhamnose isomerase.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): E228 D261 H288 D328
• Binding residue (residue number reindexed from 1): E218 D251 H278 D318
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8jq3, PDBe:8jq3, PDBj:8jq3
• PDBsum: 8jq3
• PubMed: 38430263
• UniProt: A0A171J5T1