Structure of PDB 8jnr Chain C Binding Site BS01

Receptor Information
>8jnr Chain C (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQR
TDITYQQPRLTAWYEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNE
KDSVCWHSDDEPSLGRSPIIASLSFGATRTFEMRKKPPRVKIPLDHGTLL
IMEGATQADWQHRVPKEYHSREPRVNLTFRTVYP
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8jnr Chain C Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jnr The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
Resolution3.66 Å
Binding residue
(original residue number in PDB)		H191 D193 H257
Binding residue
(residue number reindexed from 1)		H107 D109 H162
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8jnr, PDBe:8jnr, PDBj:8jnr
PDBsum8jnr
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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