Structure of PDB 8hvr Chain C Binding Site BS01

Receptor Information
>8hvr Chain C (length=1114) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTAPLRISFAKIKEPLEVPNLLALQTESFDWLLGNDAWKARVESALESG
QDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPKNSIDECKDRDF
TYAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVVVS
QLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRID
RKRKQSVTVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDI
YRKLRPGEPPTREAAQTLLENLYFNPKRYDLAKVGRYKVNKKLGADEPLD
AGVLTTDDVIATIKYLVKLHAGETETVGESGREIVVETDDIDHFGNRRIR
NVGELIQNQVRTGLARMERVVRERMTTQDVEAITPQTLINIRPVVASIKE
FFGTSQLSQFMDQNNPLSGLTHKRRLNALGPGGLSRERAGFEVRDVHPSH
YGRMCPIETPEGPNIGLIGSLASYGRINPFGFIETPYRKVVEGQVTDDVD
YLTADEEDRFVIAQANAALGDDMRFAEARVLVRRRGGEVDYVPGDDVDYM
DVSPRQMVSVATAMIPFLEHDDANRALMGANMMRQAVPLIKSESPLVGTG
MEYRSAADAGDVVKAEKAGVVQEVSADYITTTNDDGTYITYRLAKFSRSN
QGTSVNQKVIVAEGDRIIEGQVLADGPATENGEMALGKNLLVAFMPWEGH
NYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVSEE
VLADLDERGIIRIGAEVVAGDILVGKVTPKGETELTPEERLLRAIFGEKA
REVRDTSLKVPHGEIGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKI
TDGDKLAGRHGNKGVISKINPIEDMPFLEDGTPVDIILNPLAVPSRMNPG
QVLEIHLGWLASRGWDVSGLAEEWAQRLQVIGADKVEPGTNVATPVFDGA
REDELAGLLQHTIPNRDGERMVLPSGKARLFDGRSGEPFPEPISVGYMYI
LKLHHLVDDKLHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYG
AAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQS
LCLNVEVLSSDGMS
Ligand information
>8hvr Chain O (length=61) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccggagcgttcagcgttcgtttatctccccctggcactgtcatctccgtc
agaccgtcgca
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hvr Structural basis of transcription activation by Streptomyces antibiotic regulatory protein family regulator AfsR
Resolution3.35 Å
Binding residue
(original residue number in PDB)		R169 I193 W199 I356 R384 L449 E452 R453 A454 G455
Binding residue
(residue number reindexed from 1)		R154 I178 W184 I341 R369 L434 E437 R438 A439 G440
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hvr, PDBe:8hvr, PDBj:8hvr
PDBsum8hvr
PubMed38427710
UniProtQ9L0L0|RPOB_STRCO DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

[Back to BioLiP]