Structure of PDB 8hmy Chain C Binding Site BS01

Receptor Information
>8hmy Chain C (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAVEVPAGRVLSARELFAARSRSQKLPQRSHGPKDFLPDGSAAQAERLRR
CREELWQLLAEQRVERLGSLVAAEWRPEEGFVELKSPAGKFWQTMGFSEQ
GRQRLHPEEALYLLECGSIHLFHQDLPLSIQEAYQLLLTDHTVTFLQYQV
FSHLKRLGYVVRRFQPSSVPGQASSPAVVLQHISVLQTTHLPDGGARLLE
KSGGLEIIFDVYQADAVATFRKNNPGKPYARMCISGFDEPVPDLCSLKRL
SYQSGDVPLIFALVDHGDISFYSFRDFTLPQDVGH
Ligand information
>8hmy Chain T (length=90) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcucuguggcgcaauggauagcgcauuggacuucuagugacgaauaga
gcaauucaaagguuguggguucgaaucccaccagagucgg
.<<<<<<<..<<<<........>>>>.<<<<...<<<<........>>>>
.....>>>>.....<<<<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8hmy Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		R27 Q31 K41 R73 G96 A455 N464
Binding residue
(residue number reindexed from 1)		R20 Q24 K34 R66 G89 A214 N223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Biological Process
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Cellular Component
External links
PDB RCSB:8hmy, PDBe:8hmy, PDBj:8hmy
PDBsum8hmy
PubMed37028420
UniProtQ7Z6J9|SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54 (Gene Name=TSEN54)

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