Structure of PDB 8hk1 Chain C Binding Site BS01

Receptor Information
>8hk1 Chain C (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRY
MEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPN
EICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYI
NLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRV
KPLQDQNELFGKIQAEFEKKWENGTFPGWEERAQRLFSTKGKSLESLDTS
LFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQ
ARTGEEREEEEEEPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEW
RHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEY
EDSSGNVVNKKTYEDLKRQGLL
Ligand information
>8hk1 Chain H (length=148) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugau
uccucgaggaggauuuuuggagcagggagauggaauaggagcuugcuccg
uccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc
<<..>>...<<.<<.<<<...>>>.>>.>>..<<<<<........>>>>>
<<<<..>>>>...............<<<<.<<<<...<<<<....>>>>.
>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hk1 Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P393 Y394 W395 L396 K398 L399
Binding residue
(residue number reindexed from 1)		P314 Y315 W316 L317 K319 L320
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hk1, PDBe:8hk1, PDBj:8hk1
PDBsum8hk1
PubMed36797247
UniProtQ12874|SF3A3_HUMAN Splicing factor 3A subunit 3 (Gene Name=SF3A3)

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