Structure of PDB 8hb2 Chain C Binding Site BS01
Receptor Information
>8hb2 Chain C (length=254) Species:
6239
(Caenorhabditis elegans) [
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HVNYKVFIYDHIRQIAIPTTNLNSQSSLEDIIDESTSCQSVSTDGSIEID
GLTLIHNFLSESEESKILNMIDTVKWAKSKSGRRKQDYGPKVNFKHKKVK
TDTFVGMPEYADMLLNKMSEYDVKKLGNYQPFEMCNLEYEEVKKSAIEMH
QDDMWIWGNRLISINLINGSVMTLSNDNKSFLCYVHMPHRSLLCMADECR
YDWKHGVLAHHIRGRRIALTMREAAKDFAEGGELYEKYGAELIRLGNIRV
PLSK
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
8hb2 Chain C Residue 400 [
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Receptor-Ligand Complex Structure
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PDB
8hb2
Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by Caenorhabditis elegans NMAD-1A.
Resolution
3.06 Å
Binding residue
(original residue number in PDB)
H184 D186
Binding residue
(residue number reindexed from 1)
H150 D152
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.14.11.51
: DNA N(6)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0016491
oxidoreductase activity
GO:0032451
demethylase activity
GO:0035516
broad specificity oxidative DNA demethylase activity
GO:0046872
metal ion binding
GO:0051213
dioxygenase activity
GO:0141131
DNA N6-methyladenine demethylase activity
Biological Process
GO:0006260
DNA replication
GO:0010032
meiotic chromosome condensation
GO:0060903
positive regulation of meiosis I
GO:0070988
demethylation
GO:1901046
positive regulation of egg-laying behavior
GO:1905516
positive regulation of fertilization
GO:2000781
positive regulation of double-strand break repair
GO:2001252
positive regulation of chromosome organization
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Cellular Component
External links
PDB
RCSB:8hb2
,
PDBe:8hb2
,
PDBj:8hb2
PDBsum
8hb2
PubMed
38255759
UniProt
Q8MNT9
|NMAD1_CAEEL DNA N6-methyl adenine demethylase (Gene Name=nmad-1)
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