Structure of PDB 8gk4 Chain C Binding Site BS01

Receptor Information
>8gk4 Chain C (length=1031) Species: 197 (Campylobacter jejuni) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFSKFFIERPIFASVVAIIISIAGIIGLANLPVEQYPSLTPPTVQVSATY
TGADAQTIASTVATPIEDAINGVDNMIYMDSTSSPGQMKLTVYFNIGTDP
DQAAIDVNNRISAATAKLPEAVKKLGVTVRKSSSTILEVVSVYSEDSSMN
DIDIYNYVSLNILDELKRIPGVGDASAIGNKNYSMRIWLEPDLLNKFGVT
ANDVINAVNDQNAQYATGKIGEEPVVNKSPQVISITMQGRLQTPQEFENI
ILRVNEDKSFLRIKDVAKVEIGAEQYNSTGRLNTSAAVPIIINLQSGANA
VNTAKLINEKMQELSKNFPQGLKYQIPYDTTIFVKASIKEVIKTFVEALA
LVLVVMYLFLKNFKSTIIPMIAVPVSLLGTFAVLYVLGFSINLLTLFALV
LAIGIVVDDAIIVVENIDRILHEDSNISVKDAAIKAMNEVSSPVISIVLV
LCAVFIPVSFISGFVGEIQRQFALTLAISVAISGFVALTLTPSLSALFLT
RNESKPFYFIQKFNDFFDWSTSVFSSGVAYILKRTIRFVLVFCIMIGFIA
YLFKIVPSSLVPSEDQGVIMSIINLPSGSSIHRTIEEVDTINKNATQMKE
ISSSVSLIGFDLFTSSLKENAAAVFFILKDWSQREASSDQIIAQLFGQYA
ADRNALSYFLNLPPIPGLSLTGGFEMYAQNKSGKDYDAIQQDVNKMLELA
RTRKELANVRTTLDTSFPQYKLIIDRDKMKYYNLNMQDVFNTISATIGTY
YVNDFPMLGKNFQVNIRALGDFRNTQDALKNIYIRSSDNKMIPLNSFLTL
VRSAGPDDVKRFNLFPAALIQGDPAPGYTSGQAIDAIAEVAKQSLGDEYS
IAWSGSAYQEVSSKGAGAYAFVLGMIFVFLILAAQYERWLMPLAVITAVP
FAVFGSILLVALRGFDNDIYFQTGLLLLIGLSAKNAILIIEFAMEERLKK
GKSIFEAAINAAKLRFRPIIMTSLAFTFGVLPMIFATGAGSASRHSLGTG
LIGGMIAASTLAIFFVPLFFYLLENFNEWLD
Ligand information
Ligand IDCLM
InChIInChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChIKeyWIIZWVCIJKGZOK-RKDXNWHRSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc(ccc1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
CACTVS 3.341OC[CH](NC(=O)C(Cl)Cl)[CH](O)c1ccc(cc1)[N+]([O-])=O
OpenEye OEToolkits 1.5.0c1cc(ccc1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
CACTVS 3.341OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
ACDLabs 10.04ClC(Cl)C(=O)NC(C(O)c1ccc([N+]([O-])=O)cc1)CO
FormulaC11 H12 Cl2 N2 O5
NameCHLORAMPHENICOL
ChEMBLCHEMBL130
DrugBankDB00446
ZINCZINC000000113382
PDB chain8gk4 Chain C Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gk4 Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		L612 F625
Binding residue
(residue number reindexed from 1)		L612 F625
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015562 efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gk4, PDBe:8gk4, PDBj:8gk4
PDBsum8gk4
PubMed37289051
UniProtA0A1C9A1J1

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