Structure of PDB 8g9z Chain C Binding Site BS01

Receptor Information
>8g9z Chain C (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAI
MDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRAVQPKAAGSSLLN
KITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYI
IWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPD
CILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHL
IQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRAS
ASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLH
TPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVS
GYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKER
SKEDVDIEEMALKLDNAL
Ligand information
>8g9z Chain E (length=87) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggaugauccucaguggucuggggugcaggcuaaaccuguagcuguc
uagcgacagagugguucaauuccaccuuucgggcgcc
<<<<<<<....<<<<<<....>>>>>><<<<<<.....>>>>>>.<<<<<
....>>>>>.<<<<.......>>>>..>>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8g9z Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		R19 E23 R26 H30 H132 T133
Binding residue
(residue number reindexed from 1)		R9 E13 R16 H20 H117 T118
Enzymatic activity
Enzyme Commision number 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological Process
GO:0001514 selenocysteine incorporation
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g9z, PDBe:8g9z, PDBj:8g9z
PDBsum8g9z
PubMed36929010
UniProtQ9HD40|SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (Gene Name=SEPSECS)

[Back to BioLiP]