Structure of PDB 8g9f Chain C Binding Site BS01

Receptor Information
>8g9f Chain C (length=446) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGDRKGDLYPSSLQFYQHPPTENISLIEFETFAIERLKLLKAVENLGVSY
VKNSEEYSKKLELELRKLKFPYRPLHEEISDDVYDLRRKDHISHFILRLA
YCQSEDLRRWFIQQEMDLFKFRFGLLTKESVQEFLKLNDLQYVAISEDEK
NMHKEDLMNSSFGLSLTKMEDTEFYKVPFQAALDLVRPRKVFLWRGFAFI
PHKDIVSIVLNDFRAKLSKALALSARSLPVVQSDERLQPLLNHLSHSYIG
QDFSSQSNTGKISLEQIDGFAAKSFPLCMRQLHKSLRENHHLRHGGRMQY
GLFLKGIGLTLEQALQFWRLEFTKGKVDSEKFDKVYAYSIRHNYGKEGKR
TDYTPYSCMKVILSNPPSQGDYHGCPFRHSDPELLKQKLQSFKVPSSGIN
QILELVKGMHYQLACQKYFELTHSVDDCGFSLNHPNQYFAESQKLL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8g9f Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8g9f A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		P291 C293 C373 V376 C390 F392 C430 L447 P450
Binding residue
(residue number reindexed from 1)		P276 C278 C358 V361 C375 F377 C415 L432 P435
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
Cellular Component
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g9f, PDBe:8g9f, PDBj:8g9f
PDBsum8g9f
PubMed38491139
UniProtA0A1L8G3G3

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