Structure of PDB 8g3z Chain C Binding Site BS01

Receptor Information

>8g3z Chain C (length=390) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EPEWTYPRLSCPGSTFQKALLISPHRFGEIKGNSAPLIIREPFIACGPTE
CKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAA
WSGSACHDGKEWTYIGVDGPDSNALLKIKYGEAYTDTYHSYAKNILRTQE
SACNCIGGDCYLMITDGPASGVSECRFLKIREGRIIKEIFPTGRVKHTEE
CTCGFASNKTIECACRDNRYTAKRPFVKLNVETDTAEIRLMCTETYLDTP
RPNDGSITGPCESDGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMG
MGLYVKYDGDPWTDSEALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIG
IEMVHDGGKTTWHSAATAIYCLMGSGQLLWDTVTGVDMAL

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8g3z Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8g3z A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	D293 T297 D324 G344 G346
Binding residue (residue number reindexed from 1)	D217 T221 D248 G268 G270
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.2.1.18: exo-alpha-sialidase.

Gene Ontology

	Molecular Function
GO:0004308	exo-alpha-sialidase activity

	Biological Process
GO:0005975	carbohydrate metabolic process

	Cellular Component
GO:0016020	membrane
GO:0033644	host cell membrane
GO:0055036	virion membrane

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Cellular Component

External links

PDB	RCSB:8g3z, PDBe:8g3z, PDBj:8g3z
PDBsum	8g3z
PubMed	37258672
UniProt	R4KV67

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