Structure of PDB 8fzm Chain C Binding Site BS01

Receptor Information
>8fzm Chain C (length=412) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQ
Ligand information
>8fzm Chain D (length=21) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RRKRKREWDDDDDPPKKRRRL
Receptor-Ligand Complex Structure
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PDB8fzm Human importin alpha 3 in complex with Bimax2 peptide
Resolution3.0 Å
Binding residue
(original residue number in PDB)		L99 S100 D102 P105 W137 N141 S144 G145 T150 Q176 W179 N183 D187 N219 W222 R229 W264 Y268 V312 T313 G314 D316 K344 W348 N352 G356 W390 S398
Binding residue
(residue number reindexed from 1)		L28 S29 D31 P34 W66 N70 S73 G74 T79 Q105 W108 N112 D116 N148 W151 R158 W193 Y197 V241 T242 G243 D245 K273 W277 N281 G285 W319 S327
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fzm, PDBe:8fzm, PDBj:8fzm
PDBsum8fzm
PubMed
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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