Structure of PDB 8fzk Chain C Binding Site BS01

Receptor Information
>8fzk Chain C (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFV
SFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH
AHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGY
LRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAI
SYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD
EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVN
HGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPL
MNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEA
LQNHENESVYKASLSLIEKYFS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8fzk Chain C Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fzk Dimeric human importin alpha subunit
Resolution2.1 Å
Binding residue
(original residue number in PDB)		T349 Q352 D390 T393
Binding residue
(residue number reindexed from 1)		T274 Q277 D315 T318
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fzk, PDBe:8fzk, PDBj:8fzk
PDBsum8fzk
PubMed
UniProtP52292|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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