Structure of PDB 8fh3 Chain C Binding Site BS01

Receptor Information
>8fh3 Chain C (length=996) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVG
LYHLAVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEG
KVQLHLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGV
VQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVND
ATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKV
ILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGP
DELRPMLAQNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIR
VYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCP
IAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALA
HYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDC
GAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPK
IHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVR
ETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIY
ADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKC
PSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLY
MALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSE
MATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTS
TVIECHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEI
EEATTPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCD
FPALYSELKIMLNTESTCPMCSERLNAAQLKKISDCTQYLRTEEEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fh3 Chain C Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fh3 Human IFT-A complex structures provide molecular insights into ciliary transport.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		C1292 C1295 C1314 C1317
Binding residue
(residue number reindexed from 1)		C946 C949 C968 C971
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0007224 smoothened signaling pathway
GO:0008406 gonad development
GO:0030030 cell projection organization
GO:0030326 embryonic limb morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0035721 intraciliary retrograde transport
GO:0042471 ear morphogenesis
GO:0043113 receptor clustering
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050877 nervous system process
GO:0055123 digestive system development
GO:0060271 cilium assembly
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055 myotome development
GO:0065003 protein-containing complex assembly
GO:1903441 protein localization to ciliary membrane
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0030991 intraciliary transport particle A
GO:0031514 motile cilium
GO:0032391 photoreceptor connecting cilium
GO:0097542 ciliary tip
GO:0097730 non-motile cilium

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fh3, PDBe:8fh3, PDBj:8fh3
PDBsum8fh3
PubMed36775821
UniProtQ8NEZ3|WDR19_HUMAN WD repeat-containing protein 19 (Gene Name=WDR19)

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