Structure of PDB 8f5o Chain C Binding Site BS01

Receptor Information
>8f5o Chain C (length=1179) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHTSVRWSETADAVKGIRPPVNSLCYSPSGDYVVASCGVRVLVYAASTGT
LLHSLMGHQDTIYCVDYSSDGKNFASGGADRTVIVWSSQGEGIVKYQHTE
AIQALAHNPTSSQLASVSSVDWGIWSPEQPKVSKYSLPSKGLCAAWTPNG
KTLAIGMLDGTVMMLSKTSEEKVIIRRPAPVWALAFTPLRENGIDVLAIG
SWDQRLSFYNLSGTAVGRERELDFDPCSVSYFNDGEYILLSGSDHKVTLF
TKDGNRLIELASADDWIWSARQRPRQKQFCYGTNDGTISCIDITISTVHT
IYDDQYVFRKDMTNLVVHQLLVDRKMVIPCNEYVQKIATFLDKLAVQLQE
RVIVFEFFYDDDRTMRYQDIAQIRRRLECSLLCVTTGAIIVSNDKRITMY
DFQGNKRREWSMESPVQLMKVVGGMEGREILLVGLNGGQVMKVFVDNPFP
TLLHKGTAPVKSAELSSSRSRLAVIDSTNTLQVLELGEKNELLFSEDNVT
AVAFNIDVDDNIAFTTGDNTLHIKTGSLPAYQQAVRGIVVGFKANHVFNL
HYSNMMVLDVPHAHALYKYVEMRDFDRAYEVACLGVADADWKMLGLHAMS
QLRLDIARKAFTHIQDTKLVELLKSLELRRRQAKDSVLYGSILAFQGKYN
DAARQFMKTGCELKAVEMYCDLKMWDNAKKICTDEKVLKDLIRQQARWAE
ESQNFVEAASLYESCGDYAKAIGMMGQAGQVEKLMKMCRSLPTSEVTLIT
ECANFFRKHNAIPFAIEAYEKVQDHQALIGIYVAKGDWRNAFTILEKTPT
LAREVYVPWATWLADNDKFDEALEAFRAAKWPKEAMRLMETLATNSVTCR
KFRDAAFYYIHLAEEYGRFEETEKPTDVEKAARIRRSKECVRRADIYYAF
SGVYAHTTQPLPYNELSLFRTAKYLFGMCAESAIPINVGKGAILYTLSRI
ANRLEMVRTARAVFEKLQGVILPVSMMEQVDIETLLVRSKPVKDRDELLD
RCFRCNQLIAQLPMAGDRCPNCFHPCVRSFVNFECLPLVEFVLADELTDE
EAERIIVSGPFFTQLQYVLRPGRPTATYQPFVASADILKGFRRDEVFIVR
PRYGTLPVPNRYYRLMRSDVSVCLCNGCQHFFIAEDYEAECMRGSGCPLC
RYRPGKQVSRSMKQILFDMETAAAASKTS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8f5o Chain C Residue 2000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f5o Mechanism of IFT-A polymerization into trains for ciliary transport.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C1044 C1047 C1061
Binding residue
(residue number reindexed from 1)		C1002 C1005 C1019
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0035721 intraciliary retrograde transport
GO:0060271 cilium assembly
GO:0061512 protein localization to cilium
GO:1905515 non-motile cilium assembly
Cellular Component
GO:0030991 intraciliary transport particle A
GO:0097730 non-motile cilium

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8f5o, PDBe:8f5o, PDBj:8f5o
PDBsum8f5o
PubMed36563665
UniProtA0A640KU89

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