Structure of PDB 8euy Chain C Binding Site BS01

Receptor Information
>8euy Chain C (length=329) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAARPTVSIYNKDGSVSSETLALPFVFKAPIRPDLVRSVHTAVAKNKRQP
YAVSEKAGGNMCRSGRMFAPTKTWRKWHVKVNQNEKRYAIASAVAASGVP
SLLLARGHRIEEIPEVPLVVDDAVQSFQKTKEAVALLKEIKAYRDVIKVA
NSRKLRAGKGKLRNRRHVQRRGPLVVFNEDTGIVKAFRNIPGVEIVNVRR
LNLLQLAPGGHLGRFVIWTKSAFGLLDSVFGSTTEVAQLKKNYFLPENII
SNADVTRLINSDEIQSIVKAAGPSRVKRAHVQKKNPLKNKAVLSRLNPYA
KAYKANVKINSEKTPKAAGEKFLSVLHEN
Ligand information
>8euy Chain 1 (length=1433) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggagugaagcgggaaaagcucaa
auuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaaga
agcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacguc
agagagggugagaaccccgucuuuggucgauuggauaugccauauaaagc
gcuuucgaagagucgaguuguuugcagcucuaaaugggugguaucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucagucuuaccugggugagaucaguagucucucg
agacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcg
gaaaaagaauaagggaagguggcguguuuauagccuuguuguaauacguc
cacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugg
uuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugc
gaguguuugggugaugaaaacccauccgcgaagugggaacgcccuugugg
cgugcaccagagcauagcuguugggacccgaaagauggugagaaccaucu
aguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguu
uuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcag
aacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaaugua
cgcucaucagacgaaaagguguuaguucaugaacuagcccugggcgcuua
agcguacuacccauaccucaccgucuggguuagcuuugagaagcucagac
gaguaggcaggcguggagguuugugacgaagccuugggcgugagccuggg
ucgaacagccucuagugcagaucuugguggaaguagcucuagcgaaacca
cagccuggggaacgggccaggucgucgcaaugguaauucaacuuaguacg
agaggaaccguugauucagaucauugguauuugcgcggagcuaucaucug
cuggauaacggcugaacgccucuaagccagaauccgugccagaaagcgac
gagguccgcauauguauaaaaauagagguaggcuacucuccuguaucgua
gaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccau
gaaauuccaugugcggaaucgaauccauugcauacgacuuuaauguggaa
cgggguauugagauucuuuguucccaagauuug
........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<...>>.....>>>>>..<<<..<
<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<
<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((.
.....<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>
>>>.>>........<<<<<<<..>>>>>>>.....<<<<<<..>>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>
>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<
.......<<<<<<<.......<..>........>>>>>>>......>>>>
>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<...<<<<.......>>>>...>>>...<<<....<<<....>>>.
....>>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>.
.....>.>>..<<<<<<....<.<<..>>.><<<<<<<<<<...<<<.<<
<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>
>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<
<<<......<......<<<.<<<<<<<<..>>>>>>>>>>>.))).>...
.>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>
>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>
>...>>.>>>>>>>..>.....>>>>>><<.....<<....>>....>>.
...<<<<<........>>>>><<<<<<<..<<<<.<.<<<<<........
.........>>>>>.><<<<<...<<<<....<..>...>>>>..>>>>>
.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>
>><.<<<<<<<....<<.......<<<<.<<.>>..>>>>....>>....
....<<<<<.....<<<<<<<<<<<......>>>>>>>>>>>...>>>>>
..........>>>>>>>.><<<<<<.....................<<<<
<<<...<<....>>..>>.>>>>>...>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8euy Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.0 Å
Binding residue
(original residue number in PDB)
R33 L36 R38 T42 A45 K46 N47 K48 R49 Q50 Y52 V54 S55 A58 N94 M95 C96 R97 S98 R100 M101 F102 A103 P104 R109 K110 K114 N116 Q117 N118 E119 K120 R121 Y122 R140 R143 K163 T164 K165 K188 L189 R190 A191 G192 K193 K195 R197 R199 R200 R204 R205 K219 R222 N223 R234 L235 N236 P242 G243 H245 K274 K275 I293 N294 D296 Q299 A305 G306 P307 R309 V310 K311 R312 H314 V315 Q316 K318 K322 N323 A325 S328 R329 A334 Y337 N340 V341 K342 I343 N344 E346 P349 K350 A351 A352 F356 L360 H361
Binding residue
(residue number reindexed from 1)
R32 L35 R37 T41 A44 K45 N46 K47 R48 Q49 Y51 V53 S54 A57 N60 M61 C62 R63 S64 R66 M67 F68 A69 P70 R75 K76 K80 N82 Q83 N84 E85 K86 R87 Y88 R106 R109 K129 T130 K131 K154 L155 R156 A157 G158 K159 K161 R163 R165 R166 R170 R171 K185 R188 N189 R200 L201 N202 P208 G209 H211 K240 K241 I259 N260 D262 Q265 A271 G272 P273 R275 V276 K277 R278 H280 V281 Q282 K284 K288 N289 A291 S294 R295 A300 Y303 N306 V307 K308 I309 N310 E312 P315 K316 A317 A318 F322 L326 H327
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8euy, PDBe:8euy, PDBj:8euy
PDBsum8euy
PubMed36423630
UniProtQ9P784|RL4B_SCHPO Large ribosomal subunit protein uL4B (Gene Name=rpl401)

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