Structure of PDB 8eti Chain C Binding Site BS01

Receptor Information
>8eti Chain C (length=328) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAAARPTVSIYNKDGSVSSETLALPFVFKAPIRPDLVRSVHTAVAKNKRQ
PYAVSEKGNMCRSGRMFAPTKTWRKWHVKVNQNEKRYAIASAVAASGVPS
LLLARGHRIEEIPEVPLVVDDAVQSFQKTKEAVALLKEIKAYRDVIKVAN
SRKLRAGKGKLRNRRHVQRRGPLVVFNEDTGIVKAFRNIPGVEIVNVRRL
NLLQLAPGGHLGRFVIWTKSAFGLLDSVFGSTTEVAQLKKNYFLPENIIS
NADVTRLINSDEIQSIVKAAGPSRVKRAHVQKKNPLKNKAVLSRLNPYAK
AYKANVKINSEKTPKAAGEKFLSVLHEN
Ligand information
>8eti Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugauaagcgcaggaaaagaaa
auaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaa
aucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcu
uugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagg
gugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucg
aagagucgaguugcagcucuaaauggguggucaucuaaagcuaaauauug
gcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacu
uugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauugg
aaaucagucuuaccugggugagaucaguagucucucgagacuaugcacuc
uaaccuggguaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
cuaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaa
aacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaaaga
gcauagcuguugggacccgaaagauggugaaccaucuaguagcugguucc
ugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguaugua
aaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcg
ggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaag
aaaagguguuaguucaucuagacagcaggacgguggccauggaagucgga
auccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccuga
aaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagc
uuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcagcgaaaccacagccuggggggccaggcaaaaucagcggcagucaag
cgcgacguugcuuuccuaucauaccgaagcagaauucgguaagcguggga
acugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaacc
guugauucagaucauugguauuugcggcgccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgaa
uguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcga
ugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaucg
aauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugc
ugagauuaagccuuuguucccaagauuug
........................<<<<<<....>>>>>.>.........
<<....>>..<<<<<......<<>>.....>>>>>..<<<..<.......
.<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<
<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<
<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>.
.......<<<<<<>>>>>>.....<<<<<..>>>>>..>>>.........
.........................<<....>>...............<<
<<....>>>>..................................<<<<<<
<<<<<<.....<<<<<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>
>.>>>>>>>>..<<<<<<<<<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>....>>>>>>>>....>>>>>>>>>>>>..<<<<
.....>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<......
.>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>......
>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<
<<<<......<<..>>..<<<<<<<<<<...<<<.<<<<<<<....>>>>
>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...
...<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>.
...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<....
.<<.>>....>>....<<<<<....>>>>>....<<<<<.<<<<<<...<
..>...>>>>>>.<<<...<.<<<<<<<......>>>>>>>...>.>>>.
.>>>>>......<<<<<<<..<<<<.<.<<<<<.................
>>>>>.><<<<<....<.<....<<<<..>>>>...>.>...>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>.
...<<.......<<<<<<...>>.>>>>....>>........<<<<<...
.<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<
<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>
...>>>....>>>>.>>>>>...>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8eti Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.7 Å
Binding residue
(original residue number in PDB)
R33 T42 V44 A45 K46 N47 K48 Q50 Y52 S55 G93 N94 M95 C96 R97 S98 M101 F102 A103 W108 R109 K110 K114 N116 Q117 N118 E119 K120 R121 R140 R143 K163 T164 K188 L189 R190 A191 G192 K193 K195 L196 R197 N198 R199 R204 R205 K219 R222 N223 I229 R234 L235 N236 P242 G243 H245 K274 K275 I293 N294 D296 Q299 G306 P307 R309 V310 K311 R312 V315 Q316 K318 N323 A325 R329 A334 Y337 A339 N340 V341 K342 I343 N344 E346 K347 P349 K350 A351 A352 H361
Binding residue
(residue number reindexed from 1)
R33 T42 V44 A45 K46 N47 K48 Q50 Y52 S55 G58 N59 M60 C61 R62 S63 M66 F67 A68 W73 R74 K75 K79 N81 Q82 N83 E84 K85 R86 R105 R108 K128 T129 K153 L154 R155 A156 G157 K158 K160 L161 R162 N163 R164 R169 R170 K184 R187 N188 I194 R199 L200 N201 P207 G208 H210 K239 K240 I258 N259 D261 Q264 G271 P272 R274 V275 K276 R277 V280 Q281 K283 N288 A290 R294 A299 Y302 A304 N305 V306 K307 I308 N309 E311 K312 P314 K315 A316 A317 H326
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8eti, PDBe:8eti, PDBj:8eti
PDBsum8eti
PubMed36423630
UniProtQ9P784|RL4B_SCHPO Large ribosomal subunit protein uL4B (Gene Name=rpl401)

[Back to BioLiP]