Structure of PDB 8dwl Chain C Binding Site BS01

Receptor Information
>8dwl Chain C (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
Ligand information
>8dwl Chain D (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KKVEWTSDTVDNEHMGRRSSKCC
Receptor-Ligand Complex Structure
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PDB8dwl Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R96 D166 I169 D208 R221 D242 L243 Q249 V250 E252 D253 Y255 F257 F258 A259 K260 R261 F276 E287 L289 M290 C291 F293
Binding residue
(residue number reindexed from 1)		R91 D161 I164 D203 R216 D237 L238 Q244 V245 E247 D248 Y250 F252 F253 A254 K255 R256 F271 E282 L284 M285 C286 F288
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8dwl, PDBe:8dwl, PDBj:8dwl
PDBsum8dwl
PubMed37002212
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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