Structure of PDB 8dtp Chain C Binding Site BS01

Receptor Information

>8dtp Chain C (length=432) Species: 2681598 (Escherichia phage T4)

MVEIILSHLIFDQAYFSKVWPYMDSEYFESGPAKNTFKLIKSHVNEYHSV
PSINALNVALENSSFTETEYSGVKTLISKLADSPEDHSWLVKETEKYVQQ
RAMFNATSKIIEIQTNAELPPEKRNKKMPDVGAIPDIMRQALSISFDSYV
GHDWMDDYEARWLSYMNKARKVPFKLRILNKITKGGAETGTLNVLMAGVN
VGKSLGLCSLAADYLQLGHNVLYISMEMAEEVCAKRIDANMLDVSLDDID
DGHISYAEYKGKMEKWREKSTLGRLIVKQYPTGGADANTFRSLLNELKLK
KNFVPTIIIVDYLGICKSCRIRVYSENSYTTVKAIAEELRALAVETETVL
WTAAQVGKQAWDSSDVNMSDIAESAGLPATADFMLAVIETEELAAAEQQL
IKQIKSRYGDKNKWNKFLMGVQKGNQKWVEIE

Ligand information

>8dtp Chain M (length=12)

tttttttttttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8dtp Structural basis of the T4 bacteriophage primosome assembly and primer synthesis.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Y329 K358 A372 E373 S374 A375
• Binding residue (residue number reindexed from 1): Y329 K358 A372 E373 S374 A375

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0017116 single-stranded DNA helicase activity

Biological Process

• GO:0006260 DNA replication
• GO:0006268 DNA unwinding involved in DNA replication
• GO:0006269 DNA replication, synthesis of primer
• GO:0032508 DNA duplex unwinding
• GO:0039686 bidirectional double-stranded viral DNA replication
• GO:0039693 viral DNA genome replication

Cellular Component

• GO:0005829 cytosol
• GO:1990077 primosome complex

External links

• PDB: RCSB:8dtp, PDBe:8dtp, PDBj:8dtp
• PDBsum: 8dtp
• PubMed: 37474605
• UniProt: P04530|HELIC_BPT4 DnaB-like replicative helicase (Gene Name=41)