Structure of PDB 8d96 Chain C Binding Site BS01

Receptor Information
>8d96 Chain C (length=869) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGFGERNATCGRMIC
DVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYL
LEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFL
LLHAFYENNYIVPDKQIAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSII
QEFNICFTTVQRVEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQ
DLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGRE
ILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKL
YKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRR
DWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQ
FEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQD
GSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDA
VLIATWLGLDPTQFRVHHY
Ligand information
Receptor-Ligand Complex Structure
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PDB8d96 Structures of human primosome elongation complexes.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		D1002 K1053 K1075 R1081 R1082 A1138 T1140 K1141 Y1146 H1154
Binding residue
(residue number reindexed from 1)		D620 K671 K693 R699 R700 A756 T758 K759 Y764 H772
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0032479 regulation of type I interferon production
GO:1902975 mitotic DNA replication initiation
GO:1904161 DNA synthesis involved in UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0031981 nuclear lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d96, PDBe:8d96, PDBj:8d96
PDBsum8d96
PubMed37069376
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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