Structure of PDB 8cxy Chain C Binding Site BS01

Receptor Information
>8cxy Chain C (length=539) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYD
LFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLT
NKIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSE
VYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSN
VNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICIN
KFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSL
EDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVD
KSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQ
WGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKF
SYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEE
IENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxy Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		Y30 N165 Y168 K173 K193 Y221 S227 F253 I256 G257 Q346 I431 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		Y2 N127 Y130 K135 K155 Y183 S189 F215 I218 G219 Q308 I393 R394 W401 R403 K418 Y438 K473 M475 S476 Y483 P484 N485
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxy, PDBe:8cxy, PDBj:8cxy
PDBsum8cxy
PubMed36581322
UniProtQ183J3

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