Structure of PDB 8cxw Chain C Binding Site BS01

Receptor Information
>8cxw Chain C (length=538) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDL
FEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLTN
KIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEV
YKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNV
NVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINK
FETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLE
DIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDK
SEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQW
GREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFS
YEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEI
ENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxw Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		Y30 N165 Y168 H171 K173 K193 Y221 S227 F253 I256 G257 S344 F345 Q346 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		Y1 N126 Y129 H132 K134 K154 Y182 S188 F214 I217 G218 S305 F306 Q307 R393 W400 R402 K417 Y437 K472 M474 S475 Y482 P483 N484
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxw, PDBe:8cxw, PDBj:8cxw
PDBsum8cxw
PubMed36581322
UniProtQ183J3

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