Structure of PDB 8cro Chain C Binding Site BS01

Receptor Information
>8cro Chain C (length=390) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLSTIKSLIEKKGANLPENVKSELYEKLKKYNEKYKLTKAEIEAIIDDV
VKEYERALVEPGEPVGTVAAQSIGEPSTQMTLNTFHYAGVAEINVTLGLP
RIIEIVDARKNPSTPMMTVYLDEEHRYDRAKAEEVARRIEGTTLENLARS
TTLDLINFEFIVEIDPERLERSGLTMEKVVKKLESSFKSAEFEVDGYTLI
VRPKKADKISDLRRFAEKIKKHRLKGLSGVGKTIVRKEGDEYVIYTEGSN
FKQVLKVPGVDPTRTRTNNIHEIAEVLGIEAARNAIIDEIVSTMQEQGLE
VDIRHIMLVADMMTLDGIVRPIGRHGVVGEKSSVLARAAFEITVQHLFEA
AEKGEVDNLNGVIENVLIGQPVPVGTGMVKLTMKLPLRPQ
Ligand information
Receptor-Ligand Complex Structure
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PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R325 E342 I343 Q346
Binding residue
(residue number reindexed from 1)		R324 E341 I342 Q345
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M5|RPO1C_PYRFU DNA-directed RNA polymerase subunit Rpo1C (Gene Name=rpo1C)

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