Structure of PDB 8cm9 Chain C Binding Site BS01

Receptor Information

>8cm9 Chain C (length=704) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKALNMPVIPMNTIAE
AVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQ
YGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEP
NIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGM
DVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLG
TDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPD
HMIK

Ligand information

>8cm9 Chain H (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

FMPKYSI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8cm9 Structure of human O-GlcNAc transferase in complex with UDP and tP11
Resolution	2.8 Å
Binding residue (original residue number in PDB)	F723 I790 N791 R792 G793 L808 Q812 S833 Y835 G836 L837
Binding residue (residue number reindexed from 1)	F402 I456 N457 R458 G459 L474 Q478 S499 Y501 G502 L503

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:8cm9, PDBe:8cm9, PDBj:8cm9
PDBsum	8cm9
PubMed	37819980
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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