Structure of PDB 8clj Chain C Binding Site BS01

Receptor Information
>8clj Chain C (length=579) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HCRGMAPNGLPNHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLAWKWHL
LSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERWDV
SFFTGGPLWALDWCPVPEGAGASQYVALFSSPDMNETHPLSQLHSGPGLL
QLWGLGTLQQESCPGNRAHFVYGIACDNGCIWDLKFCPSGAWELPGTPRK
APLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPPDAVKPAIYKVQCVA
TLQVGSMQATDPSECGQCLSLAWMPTRPHQHLAAGYYNGMVVFWNLPTNS
PLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLVSAGSDRKIK
FWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYI
DAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMAL
NPINVKRPVERRFPIYKADLIPYRTYTETVNHHYLLFQDTDLGSFHDLLR
REPMLRMQEGEGHSQLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLV
RIHFVRGLASPLGHRMQLESRAHFNAMFQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8clj Structural insights into human TFIIIC promoter recognition.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H290 S680 N743
Binding residue
(residue number reindexed from 1)		H1 S391 N454
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006383 transcription by RNA polymerase III
GO:0042791 5S class rRNA transcription by RNA polymerase III
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005654 nucleoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8clj, PDBe:8clj, PDBj:8clj
PDBsum8clj
PubMed37418517
UniProtQ8WUA4|TF3C2_HUMAN General transcription factor 3C polypeptide 2 (Gene Name=GTF3C2)

[Back to BioLiP]