Structure of PDB 8ci9 Chain C Binding Site BS01

Receptor Information

>8ci9 Chain C (length=306) Species: 93608 (Sinopodophyllum hexandrum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LRLPVIDLSMKNLKPGTTSWNSVRTQVREALEEYGCFEAVIDAVSPELQK
AVCNKGHELLNLPLETKMLNGNKPEYDGFTSIPNLNEGMGVGRITDLEKV
ERFTNLMWPEGNKDFCETVYSYGKRMAEVDHILKMMVFESFGMEKHFDSF
CESTNYLLHFMRYQQPGKDGRSPALSLHKDKSILTIVNQNDVKGLEFETK
DGEWILPTADNHIVLLGDCFMAWSNGRLHSPLHRVTLVANQARLSTSSFS
FPKDIIETPAELVDEEHPLLFNPFEITELLAYCFTKEGAKAVCDLKQYKA
YTGALE

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

8ci9 Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ci9 Structure and mutation of deoxypodophyllotoxin synthase (DPS) from Podophyllum hexandrum
Resolution	1.41 Å
Binding residue (original residue number in PDB)	H184 D186 H239
Binding residue (residue number reindexed from 1)	H178 D180 H233
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.20.8: (-)-deoxypodophyllotoxin synthase.

Gene Ontology

	Molecular Function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

	Biological Process
GO:0009611	response to wounding
GO:0009699	phenylpropanoid biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:8ci9, PDBe:8ci9, PDBj:8ci9
PDBsum	8ci9
PubMed
UniProt	A0A0N9HQ36\|2ODD_SINHE Deoxypodophyllotoxin synthase (Gene Name=2-ODD)

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