Structure of PDB 8be0 Chain C Binding Site BS01

Receptor Information
>8be0 Chain C (length=731) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMK
WAMCSNFPLALTKGDMANRIPLEYKGIQLKTNKGQMCSIAAVTWWNTYGP
IGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEM
PPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLA
YMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGGNKLTES
RSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGG
DVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKI
GIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLIILCMVF
SQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQWGYEES
PKASELHGINESMNASDYTLKGVVVTRNVIDDFSTEKVSITKNLSLIKRT
GEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLV
TLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEV
MKTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLF
SYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLG
DFKTIEELEKLKPGEKANILLYQGKPVKVVK
Ligand information
Receptor-Ligand Complex Structure
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PDB8be0 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		R40 K43 I203 Y207 R216 R218 R425
Binding residue
(residue number reindexed from 1)		R40 K43 I197 Y201 R210 R212 R419
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8be0, PDBe:8be0, PDBj:8be0
PDBsum8be0
PubMed36596301
UniProtQ5V8X3

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