Structure of PDB 8b9n Chain C Binding Site BS01

Receptor Information
>8b9n Chain C (length=236) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALVYSGVETLGKELFMYFGH
RALRIHFGMKGSILINPSPALAVQLTRDLICFYDSSVELRNSVESQQRVR
EMEELDICSPKFSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIKNEA
LFDSGLHPAVKVCQLSDKQARHLVKMTRDFSILFYRCCKAGSAISKHCKV
YKRPNCGQCHSKITVCRFGENSRMTYFCPHCQKDGL
Ligand information
Receptor-Ligand Complex Structure
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PDB8b9n Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site
Resolution2.0 Å
Binding residue
(original residue number in PDB)		M1 V2 E3 K82 R94 H96 M99 Q185 N193 I194 Y250 R272
Binding residue
(residue number reindexed from 1)		M1 V2 E3 K42 R54 H56 M59 Q136 N144 I145 Y201 R223
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8b9n, PDBe:8b9n, PDBj:8b9n
PDBsum8b9n
PubMed
UniProtQ8K203|NEIL3_MOUSE Endonuclease 8-like 3 (Gene Name=Neil3)

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