Structure of PDB 8asw Chain C Binding Site BS01

Receptor Information
>8asw Chain C (length=527) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEKERFIQCCADITLELTDSLTSGTTREINLNGLITKYSKKYKLKQQPRL
TDIINSIPDQYKKYLLPKLKAKPVRTASGIAVVAVMCKPHRCPHIAYTGN
ICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGRVEQLKQ
LGHSIDKVEYVLMGGTFMSLPKEYREDFIVKLHNALSGFNGNDIDEAILY
SQQSLTKCVGITIETRPDYCTQTHLDDMLKYGCTRLEIGVQSLYEDVARD
TNRGHTVRSVCETFAVSKDAGYKVVSHMMPDLPNVGMERDIEQFKEYFEN
PDFRTDGLKIYPTLVIRGTGLYELWKTGRYKSYSANALVDLVARILALVP
PWTRIYRVQRDIPMPLVTSGVDNGNLRELALARMKDLGTTCRDVRTREVG
IQEVHHKVQPDQVELIRRDYYANGGWETFLSYEDPKKDILIGLLRLRKAS
KKYTYRKEFTSQRTSIVRELHVYGHQGFGTLLMEEAERIAKEEHGSEKIS
VISGVGVRNYYGKLGYELDGPYMSKRI
Ligand information
>8asw Chain X (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcacauggcgcaguugguagcgcgcuucccuugcaaggaagaggucau
cgguucgauuccgguugcgucca
<<<<.<<..<<<<........>>>>.<<<<<.......>>>>>......<
<<<.......>>>>.>>.>>>>.
Receptor-Ligand Complex Structure
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PDB8asw Cryo-EM structure of the fully assembled Elongator complex.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		T52 K53 K59 Q63 R65 L66 R91 V98 Y136 P141 T142 R160 L167 M179 R370 R373 R376 D377 R393 E394 R411
Binding residue
(residue number reindexed from 1)		T36 K37 K43 Q47 R49 L50 R75 V82 Y120 P125 T126 R144 L151 M163 R354 R357 R360 D361 R377 E378 R395
Enzymatic activity
Enzyme Commision number 2.3.1.311: tRNA carboxymethyluridine synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003824 catalytic activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0106261 tRNA uridine(34) acetyltransferase activity
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417 regulation of translation
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asw, PDBe:8asw, PDBj:8asw
PDBsum8asw
PubMed36617428
UniProtQ02908|ELP3_YEAST Elongator complex protein 3 (Gene Name=ELP3)

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