Structure of PDB 8asv Chain C Binding Site BS01

Receptor Information
>8asv Chain C (length=464) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTS
MRAIRARYDPYEQARGRVEQLKQLGHSIDKVEYVLMGGTFMSLPKEYRED
FIVKLHNALSGFNGNDIDEAILYSQQSLTKCVGITIETRPDYCTQTHLDD
MLKYGCTRLEIGVQSLYEDVARDTNRGHTVRSVCETFAVSKDAGYKVVSH
MMPDLPNVGMERDIEQFKEYFENPDFRTDGLKIYPTLVIRGTGLYELWKT
GRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVTSGVDNGNLR
ELALARMKDLGTTCRDVRTREVGIQEVHHKVQPDQVELIRRDYYANGGWE
TFLSYEDPKKDILIGLLRLRKASKKYTYRKEFTSQRTSIVRELHVYGSVV
PLHSRDPRKFQHQGFGTLLMEEAERIAKEEHGSEKISVISGVGVRNYYGK
LGYELDGPYMSKRI
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8asv Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8asv Cryo-EM structure of the fully assembled Elongator complex.
Resolution4.35 Å
Binding residue
(original residue number in PDB)		C108 H110 I117 C118 C121 Q134
Binding residue
(residue number reindexed from 1)		C15 H17 I24 C25 C28 Q41
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.311: tRNA carboxymethyluridine synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003824 catalytic activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0106261 tRNA uridine(34) acetyltransferase activity
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417 regulation of translation
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asv, PDBe:8asv, PDBj:8asv
PDBsum8asv
PubMed36617428
UniProtQ02908|ELP3_YEAST Elongator complex protein 3 (Gene Name=ELP3)

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