Structure of PDB 8abl Chain C Binding Site BS01

Receptor Information
>8abl Chain C (length=383) Species: 4952 (Yarrowia lipolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MALRKKNSLLNMANSYVLDSPQPSNLNYFWNFGSLLALCLVIQLATGITL
AMHYTSHASLAFDSVEHIMRDVNFGWFIRYAHANTASFFFICIYAHMGRN
IYYGSYKTPRVLPWSIGVIIFLLLIITAFMGYVLVFGQMSLWGATVICNL
VSAIPWLGEDIVHFLWGGFSVGNPTLQRFFALHYLMPFVLAVFALLHLIA
LHTAGSSNPLGITSNVDKLSMHPYYSFKDLITVFAFLLMFTLFVFFSPDK
LGHPDNYIPANPMVTPASIVPEWYLLPFYAILRAIPDKLGGVIAMVAAIL
ILLILPIVDRSIIRGNAFKPISKLLFGFFICNFLLLGVLGQVHIEPPFIV
LGQICTIFYFSYFLILLPMVSTIENIFFYIGSL
Ligand information
Ligand IDHEM
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
InChIKeyKABFMIBPWCXCRK-RGGAHWMASA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
CACTVS 3.385CC1=C(CCC(O)=O)C2=Cc3n4[Fe]5|6|N2=C1C=c7n5c(=CC8=N|6C(=Cc4c(C)c3CCC(O)=O)C(=C8C=C)C)c(C)c7C=C
ACDLabs 12.01C=1c3c(c(c4C=C5C(=C(C=6C=C7C(=C(C8=CC=2C(=C(C=1N=2[Fe](n34)(N5=6)N78)CCC(=O)O)C)\C=C)C)\C=C)C)C)CCC(=O)O
FormulaC34 H32 Fe N4 O4
NamePROTOPORPHYRIN IX CONTAINING FE;
HEME
ChEMBL
DrugBankDB18267
ZINC
PDB chain8abl Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8abl Analysis of the conformational heterogeneity of the Rieske iron-sulfur protein in complex III 2 by cryo-EM.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Q43 G47 L50 R79 H82 A86 T127 G131 L134 V135 H183 Y184 P187
Binding residue
(residue number reindexed from 1)		Q43 G47 L50 R79 H82 A86 T127 G131 L134 V135 H183 Y184 P187
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0022904 respiratory electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045275 respiratory chain complex III

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8abl, PDBe:8abl, PDBj:8abl
PDBsum8abl
PubMed36598500
UniProtQ9B6D0|CYB_YARLI Cytochrome b (Gene Name=COB)

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