Structure of PDB 7z6s Chain C Binding Site BS01

Receptor Information
>7z6s Chain C (length=332) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIH
QAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEV
VVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHQIGTHYLRG
VNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLY
YTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSK
DQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPH
FMQDLARYRQQLEHIMATNRLDEAELGRLLPD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z6s Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z6s Posttranslational modification of microtubules by the MATCAP detyrosinase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H280 H285 E316
Binding residue
(residue number reindexed from 1)		H141 H146 E177
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.17.17: tubulinyl-Tyr carboxypeptidase.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0106423 tubulin-tyrosine carboxypeptidase
Biological Process
GO:0006508 proteolysis
GO:0007420 brain development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z6s, PDBe:7z6s, PDBj:7z6s
PDBsum7z6s
PubMed35482892
UniProtQ68EN5|MACA1_HUMAN Microtubule-associated tyrosine carboxypeptidase 1 (Gene Name=MATCAP1)

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