Structure of PDB 7z42 Chain C Binding Site BS01

Receptor Information
>7z42 Chain C (length=718) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMK
WAMCSNFPLALTKGDMANRIPLEYKGIQLKTNAEDIGTKGQMCSIAAVTW
WNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLN
PLTKEMPPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMI
TPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGG
NKLTESRSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCL
AAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGN
GTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLI
ILCMVFSQDTRMFQGVRGEISPMYQLQRYFLNRSNDLFDQWGYEESPKAS
ELHGINESMNASDYTLKGVVVTEKVSITKNLSLIKRTGEVIMGANDVSEL
ESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLVTLKAQFLLGKEDM
FQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVMKTDQFIKLLPFC
FSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLFSYNPQTEVLTICG
RMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKP
GEKANILLYQGKPVKVVK
Ligand information
>7z42 Chain G (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YSPTSPSYSPTSPSYSPTSPS
Receptor-Ligand Complex Structure
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PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution2.418 Å
Binding residue
(original residue number in PDB)		R134 I135 W553 K556 N557 T560 L561 Q564 D571 M572 W575
Binding residue
(residue number reindexed from 1)		R134 I135 W531 K534 N535 T538 L539 Q542 D549 M550 W553
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8X3

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