Structure of PDB 7yx9 Chain C Binding Site BS01

Receptor Information
>7yx9 Chain C (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFA
SFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREP
NVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLP
FLPSTEDVYDCRVEHWGLDEPLLKHWEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yx9 MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		Q9 F24 F51 A52 S53 F54 G58 N62 V65 D66 N69 I72 M73
Binding residue
(residue number reindexed from 1)		Q7 F22 F49 A50 S51 F52 G56 N60 V63 D64 N67 I70 M71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7yx9, PDBe:7yx9, PDBj:7yx9
PDBsum7yx9
PubMed37142807
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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