Structure of PDB 7yfi Chain C Binding Site BS01

Receptor Information
>7yfi Chain C (length=745) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM
ALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTR
MSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGR
AAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSAS
EDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLING
KNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRV
LMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIP
NDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEF
TVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTY
EVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERA
QYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVA
VMLYLLDRFSPSAMWFSWGVLLNFSARILGMVWAGFAMIIVASYTANLAA
FLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMY
RHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELF
FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain7yfi Chain C Residue 808 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yfi Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		F484 T518 R523 S687 S688
Binding residue
(residue number reindexed from 1)		F460 T494 R499 S634 S635
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yfi, PDBe:7yfi, PDBj:7yfi
PDBsum7yfi
PubMed36959261
UniProtP35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)

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