Structure of PDB 7xam Chain C Binding Site BS01 |
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| >7xam Chain A (length=3062)
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aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaag
gacguaggaggcugcgauaagccucggggagcugucaaccgagcguugau
ccgaggauguccgaauggggaaacccggcacgagugaugucgugucacca
ggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucu
caguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcga
gcgaaagcggaggauggcuaaaccguaugcaugugauaccggguaggggu
ugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggag
ggcagugagaaaauguugugguuagcggaaauggcuugggauggccugcc
guagacggugagagcccgguacgugaaaacccgacgucugucuugauggu
guucccgaguagcagcgggcccguggaaucugcugugaaucugccgggac
cacccgguaagccugaauacuucccagugaccgauagcggauuaguaccg
ugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaa
accgugcgcuuacaauccgucagagcccucgacgugucguggggugaugg
cgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguua
acccgggugggguagccgcagcgaaagcgagucugaauagggcguaucca
cacaagagugugugguguagugguguguucuggacccgaagcggagugau
cuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaac
ccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggc
caaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcag
cgucgcauguuucuugccggagguagagcuacuggauggccgaugggccc
cacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagag
ugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaaca
gcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggau
gugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuug
aaagagugcguaauagcucacuggucaagugauugugcgccgauaaugua
gcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcugg
guaggggagcguccugcauccggugaagccgccgagugaucgaguggugg
agggugugggagugagaaugcaggcaugaguagcgauuaggcaagugaga
accuugcccgccgaaagaccaaggguuccugggccaggccaguccgccca
gggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaac
ggguugauauucccguacccguguaugugcguccaugaugaaucagcggu
acuaaccauccaugggaccuucguugguaguagucaagcgauggggugac
gcaggaagguagccguaccggucagugguaauaccgggguaagccuguag
ggagucagauagguaaauccgucuggcauauauccugagaggugaugcau
agccgagugaggcgaauucggugauccuaugcugccgagaaaagccucua
gcgaggacauacacggcccguaccccaaaccaacacagguggucagguag
agaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaug
cccccguaacuucgggagaagggggacccacauggcguguaagccuuuac
ggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacu
aaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgc
cugcccggugcuggaagguuaagaggacccguuaacucccuuugggggug
aagcggagaauuuaagccccaguaaacggcgguggucauccuaagguagc
gaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuu
cucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagau
gcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacu
ugguauuggugcucgauacgguuuguguaggauaggugggagacugugaa
gcucacacgccaguguggguggagucguuguugaaauaccacucugaucg
uauugggccucuaaccucggaccguauauccgguucagggacagugccug
guggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcc
caaagguucccucaaccuggacggcaaucagguguugaguguaagugcac
aagggagcuugacugcgagacggacaugucgagcagggacgaaagucggg
acuagugauccggcaccucugaguggaaggggugucgcucaacggauaaa
agguaccccggggauaacaggcugaucuuccccaagaguccauaucgacg
ggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagca
ggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcugggu
uuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaag
cuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucu
gguauaccaguugucccaccaggggcacggcuggauagccacguucggac
aggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggc
uucucacccucuaggagggauaaggccccccgcagaccacgggauugaua
gaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccgg
ccgaaaacuuac |
<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<
<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>.
.....>>>>>.>.........<<.....>>..<<<<<<.....<<.....
>>....>>>>>>...<<<....<<<<<<<<<<.........(((((....
.>>>>>>>>>>......<<<<..<.....<<<<<<<))))).>>>>>>><
<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((.
.....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>.
..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<
<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<.
...>>....>>.........<<<<....>>>>..................
>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>
>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<..
.<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>....<<<
<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<...
..<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<
<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>
>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><
<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<
....>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>
>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<.....
.>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..
<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>..
.......<<......>>...>>>>>....>>>>>>>>>.>>.........
..)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>.
...>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>..
.>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.....
..>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>
>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<
<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<.
.....<<<<..>>>>.....>>>>>>>.....>>>>.<<...<<<<<...
<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<
<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>..
.<<<......>>>.....>>>>...>>>...>>>>........>>>>>..
>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.
....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....
<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....
>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.....
....>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<
...<<....<<<..........<......<<...<<<<<<...>>>>>>.
...>>......>........>>>....>>.....................
..........<<<<<.......>>>>>...........>>>>..>>.>>>
>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......)
)>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<
.<<<<<.<<.<<<<<<<<<<<<.............<<<<..<<<......
<<<<<<<<....>>>>>>>>...>>>............>>>.>...>>>>
>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>
>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<
<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>..
..>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>
)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............
>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>
>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......
>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>.
...<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<
<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<
<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...
<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>
>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<
<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>
>>....>>>>.. |
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| PDB | 7xam Cryo-EM structures reveal a unique conformational dynamics of the Mycobacterium 23S rRNA helices |
| Resolution | 3.5 Å |
Binding residue
(original residue number in PDB) | R4 K7 P8 T10 R13 R14 F21 K31 P36 H38 G39 K40 G42 R43 N44 H46 G47 R48 I49 T50 T51 K54 G56 H58 K59 R60 A61 Y62 R63 R68 Y84 P86 R88 D99 G100 K102 R148 G150 K154 L155 A156 R157 S158 A159 G160 R176 M177 P178 S179 E181 R183 A199 S202 N205 W206 G207 K208 A209 G210 R211 W214 R218 P219 T220 V221 R222 G223 V224 V225 M226 V229 D230 H231 H233 G234 E237 P246 P249 W250 T257 R258 K259 N261 S264 K266 R270 R272 K276 |
Binding residue
(residue number reindexed from 1) | R3 K6 P7 T9 R12 R13 F20 K30 P35 H37 G38 K39 G41 R42 N43 H45 G46 R47 I48 T49 T50 K53 G55 H57 K58 R59 A60 Y61 R62 R67 Y83 P85 R87 D98 G99 K101 R147 G149 K153 L154 A155 R156 S157 A158 G159 R175 M176 P177 S178 E180 R182 A198 S201 N204 W205 G206 K207 A208 G209 R210 W213 R217 P218 T219 V220 R221 G222 V223 V224 M225 V228 D229 H230 H232 G233 E236 P245 P248 W249 T256 R257 K258 N260 S263 K265 R269 R271 K275 |
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| Enzyme Commision number |
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