Structure of PDB 7x6i Chain C Binding Site BS01

Receptor Information
>7x6i Chain C (length=687) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINC
MDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELL
LSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKR
VTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSED
PILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSREL
EIILNHRDDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHW
VVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTF
LFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGF
TEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLI
AEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLV
LLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFW
SVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS
YQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPDSLIQNQHYQEV
IRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSF
Ligand information
Ligand IDYZY
InChIInChI=1S/C37H70O5/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-36(39)41-34-35(33-38)42-37(40)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h17-18,35,38H,3-16,19-34H2,1-2H3/b18-17-/t35-/m0/s1
InChIKeyDOZKMFVMCATMEH-OZKTZCCCSA-N
SMILES
SoftwareSMILES
CACTVS 3.370CCCCCCCCCCCCCCCC(=O)O[C@@H](CO)COC(=O)CCCCCCC\C=C/CCCCCCCC
OpenEye OEToolkits 1.7.6CCCCCCCCCCCCCCCC(=O)OC(CO)COC(=O)CCCCCCCC=CCCCCCCCC
OpenEye OEToolkits 1.7.6CCCCCCCCCCCCCCCC(=O)O[C@@H](CO)COC(=O)CCCCCCC/C=C\CCCCCCCC
ACDLabs 12.01O=C(OC(CO)COC(=O)CCCCCCC\C=C/CCCCCCCC)CCCCCCCCCCCCCCC
CACTVS 3.370CCCCCCCCCCCCCCCC(=O)O[CH](CO)COC(=O)CCCCCCCC=CCCCCCCCC
FormulaC37 H70 O5
Name(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate
ChEMBL
DrugBank
ZINCZINC000040164793
PDB chain7x6i Chain B Residue 805 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x6i Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Resolution3.93 Å
Binding residue
(original residue number in PDB)		L514 L521 Y524 Q573 F576
Binding residue
(residue number reindexed from 1)		L487 L494 Y497 Q546 F549
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x6i, PDBe:7x6i, PDBj:7x6i
PDBsum7x6i
PubMed37137991
UniProtQ9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)

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