Structure of PDB 7wx3 Chain C Binding Site BS01

Receptor Information
>7wx3 Chain C (length=258) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLE
GREVMMVTSGAVAFGKQKLAQELLMSLSMRETLNLEPRAAAAVGQSGLMS
LYDAMFAQYGVKIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINT
NDAVSPPMFIPIKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGA
KLMHTYTSDDSNSIMDSKVKAATWALDRGVSVVICNGMQEKAIKTIIGGR
KVGTFFTE
Ligand information
>7wx3 Chain G (length=14) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QELLMSLSMRETLN
Receptor-Ligand Complex Structure
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PDB7wx3 Structural basis of dynamic P5CS filaments.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E116 M119 L121 S122 M123 R124
Binding residue
(residue number reindexed from 1)		E72 M75 L77 S78 M79 R80
Enzymatic activity
Enzyme Commision number 1.2.1.41: glutamate-5-semialdehyde dehydrogenase.
2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wx3, PDBe:7wx3, PDBj:7wx3
PDBsum7wx3
PubMed35286254
UniProtQ9VNW6

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