Structure of PDB 7wrc Chain C Binding Site BS01

Receptor Information
>7wrc Chain C (length=930) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFAL
KPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEE
NIVAIGIAAWGMVSNRDTLIDEGHFSAYILDNNHTHLLLVDNGCHGHPTV
EAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSK
IPCVVVEGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIK
WLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQ
LKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLE
NGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVA
NFRRRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAK
VKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGG
SNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIP
LVGCGLVSFRKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDF
HSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIML
QRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLA
MFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLN
IPFPFVVFAYFYMVVKKCFKFRNEDNETLAWEGVMKENYLVKINTKANDN
SEEMRHRFRQLDSKLNDLKSLLKEIANNIK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7wrc Chain C Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wrc Structures of a mammalian TRPM8 in closed state.
Resolution3.21 Å
Binding residue
(original residue number in PDB)		E782 Q785 N799 D802 R842
Binding residue
(residue number reindexed from 1)		E622 Q625 N639 D642 R682
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wrc, PDBe:7wrc, PDBj:7wrc
PDBsum7wrc
PubMed35662242
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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